Article

Hidden stop codons orchestrate mRNA fate by ambushing ribosomal frameshifting associated with codon usage

2026-01-15

Abstract excerpt

In eukaryotes, the mRNA stability is generally shaped by codon usage bias, the uneven preferences for synonymous codons, in a translation-dependent manner. However, the conserved mechanism linking codon to mRNA decay remains elusive. Hidden stop codons (HSCs), defined as stop codons located in the +1 or -1 frame relative to canonical ORF, are widespread across all genomes but largely uncharacterized. Here, we demo...

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Literature Corpus work: bdce7bf7-0b80-584b-a543-3191ae34ffcb
DOI: 10.64898/2026.01.14.699446

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