Article

iCodon: ideal codon design for customized gene expression

2021-05-07

Abstract excerpt

Messenger RNA (mRNA) stability substantially impacts steady-state gene expression levels in a cell. mRNA stability, in turn, is strongly affected by codon composition in a translation-dependent manner across species, through a mechanism termed codon optimality. We have developed iCodon ( www.iCodon.org ), an algorithm for customizing mRNA expression through the introduction of synonymous codon substitutions into...

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Literature Corpus work: 80ae89ca-c977-5ffa-888e-a67de5d0bf05
DOI: 10.1101/2021.05.06.442969

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