Back to search

Article

Discovery of RNA polymerase α-subunit protein as a novel quorum sensing reprograming factor in <i>Pseudomonas aeruginosa</i>

2022-08-01

Abstract excerpt

LasR is a master regulator of quorum-sensing (QS) in Pseudomonas aeruginosa. LasR-null mutants commonly appear in lung isolates from chronically infected cystic fibrosis (CF) patients. However, numerous such CF isolates have a QS-active phenotype, but factors underlying QS-reprogramming in LasR-null mutants remain largely unknown. Mutations in the transcriptional regulator gene mexT are well known to be responsi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
582cda23-1d73-5692-afe2-c9a9ac45b946
DOI
10.1101/2022.08.01.502315
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Discovery of RNA polymerase α-subunit protein as a novel quorum sensing reprograming factor in <i>Pseudomonas aeruginosa</i>DOI 10.1101/2022.08.01.502315
New Evolutionary Insights into RpoA: A Novel Quorum Sensing Reprograming Factor in Pseudomonas aeruginosa.Semantic proximity
Modulation of the <i>Pseudomonas aeruginosa</i> quorum sensing cascade by MexT-regulated factorsSemantic proximity
Novel dual regulatory roles of RpoA in quorum sensing regulation and social behavior switching in Pseudomonas aeruginosa.Semantic proximity
Non-hierarchical, RhlR-regulated acyl-homoserine lactone quorum sensing in a cystic fibrosis isolate of <i>Pseudomonas aeruginosa</i>Semantic proximity
Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulenceSemantic proximity
Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation.Semantic proximity
Multidrug-resistant Pseudomonas aeruginosa is predisposed to lasR mutation through up-regulated activity of efflux pumps in non-cystic fibrosis bronchiectasis patients.Semantic proximity
Global reprogramming of virulence and antibiotic resistance in <i>Pseudomonas aeruginosa</i> by a single nucleotide polymorphism in the elongation factor-encoding gene, <i>fusA1</i>Semantic proximity
Inactivation of MexT in Pseudomonas aeruginosa PAO1 destabilizes cooperation and favors the emergence of a unique quorum sensing variant.Semantic proximity
LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa.Semantic proximity
Tobramycin adaptation alters the antibiotic susceptibility of <i>Pseudomonas aeruginosa</i> quorum sensing-null mutantsSemantic proximity
Transcription-associated mutation of lasR in Pseudomonas aeruginosa.Semantic proximity
Select a neighboring publication to make it the new centre.