Article

Tobramycin adaptation alters the antibiotic susceptibility of <i>Pseudomonas aeruginosa</i> quorum sensing-null mutants

2023-01-14

Abstract excerpt

<h4>ABSTRACT</h4> The opportunistic bacterium Pseudomonas aeruginosa uses the LasR-I quorum sensing system to increase resistance to the aminoglycoside antibiotic tobramycin. Paradoxically, lasR -null mutants are commonly isolated from chronic human infections treated with tobramycin, suggesting there may be a mechanism allowing the lasR -null mutants to persist under tobramycin selection. We hypothesized that...

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Literature Corpus work: 1c8502ef-2d0d-5aca-8f23-055b9cf6275f
DOI: 10.1101/2023.01.13.523864

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