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Article

Multidrug-resistant Pseudomonas aeruginosa is predisposed to lasR mutation through up-regulated activity of efflux pumps in non-cystic fibrosis bronchiectasis patients.

Frontiers in cellular and infection microbiology - 1 Jan 2022

Ding Fengming, Han Lei, Xue Yishu, Yang Iris Tingshiuan, Fan Xinxin, Tang Rong, Zhang Chen, Zhu Miao, Tian Xue, Shao Ping, Zhang Min

Abstract excerpt

Background: Multidrug-resistant (MDR) Pseudomonas aeruginosa is a frequent opportunistic pathogen that causes significant mortality in patients with non-cystic fibrosis bronchiectasis (NCFB). Although the quorum sensing (QS) system is a potential target for treatment, lasR mutants that present with a QS-deficient phenotype have been frequently reported among clinical P. aeruginosa isolates. We aimed to...

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Identifiers

PMID: 35967851
DOI: 10.3389/fcimb.2022.934439
PMCID: PMC9363577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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