Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New Evolutionary Insights into RpoA: A Novel Quorum Sensing Reprograming Factor in Pseudomonas aeruginosa.

Molecular biology and evolution - 4 Oct 2023

Cai Wenjie, Liao Huimin, Lu Mingqi, Zhou Xiangting, Cheng Xiaoyan, Staehelin Christian, Dai Weijun

Abstract excerpt

Quorum-sensing (QS) coordinates the expression of virulence factors in Pseudomonas aeruginosa, an opportunistic pathogen known for causing severe infections in immunocompromised patients. QS has a master regulator, the lasR gene, but in clinical settings, P. aeruginosa isolates have been found that are QS-active but LasR-null. In this study, we developed an experimental evolutionary approach to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Biological Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Mutation

Share to Pseudomonas aeruginosa

Share to Quorum Sensing

Share to Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 37708386
DOI: 10.1093/molbev/msad203
PMCID: PMC10566545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New Evolutionary Insights into RpoA: A Novel Quorum Sensing Reprograming Factor in Pseudomonas aeruginosa.PMID 37708386Read ↗

Discovery of RNA polymerase α-subunit protein as a novel quorum sensing reprograming factor in <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

Novel dual regulatory roles of RpoA in quorum sensing regulation and social behavior switching in Pseudomonas aeruginosa.Semantic proximity Read ↗

Modulation of the <i>Pseudomonas aeruginosa</i> quorum sensing cascade by MexT-regulated factorsSemantic proximity Read ↗

Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation.Semantic proximity Read ↗

Inactivation of MexT in Pseudomonas aeruginosa PAO1 destabilizes cooperation and favors the emergence of a unique quorum sensing variant.Semantic proximity Read ↗

The end of the reign of a “master regulator’’? A defect in function of the LasR quorum sensing regulator is a common feature of Pseudomonas aeruginosa isolatesSemantic proximity Read ↗

Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulenceSemantic proximity Read ↗

Multidrug-resistant Pseudomonas aeruginosa is predisposed to lasR mutation through up-regulated activity of efflux pumps in non-cystic fibrosis bronchiectasis patients.Semantic proximity Read ↗

LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa.Semantic proximity Read ↗

Relationship of the transcription factor MexT to quorum sensing and virulence in Pseudomonas aeruginosaSemantic proximity Read ↗

Selection for increased quorum-sensing cooperation in Pseudomonas aeruginosa through the shut-down of a drug resistance pump.Semantic proximity Read ↗

Non-hierarchical, RhlR-regulated acyl-homoserine lactone quorum sensing in a cystic fibrosis isolate of <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.