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Article

LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa.

mBio - 4 Oct 2016

Feltner John B, Wolter Daniel J, Pope Christopher E, Groleau Marie-Christine, Smalley Nicole E, Greenberg E Peter, Mayer-Hamblett Nicole, Burns Jane, Déziel Eric, Hoffman Lucas R, Dandekar Ajai A

Abstract excerpt

Chronic Pseudomonas aeruginosa infections cause significant morbidity in patients with cystic fibrosis (CF). Over years to decades, P. aeruginosa adapts genetically as it establishes chronic lung infections. Nonsynonymous mutations in lasR, the quorum-sensing (QS) master regulator, are common in CF. In laboratory strains of P. aeruginosa, LasR activates transcription of dozens of genes, including that for another...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27703072
DOI: 10.1128/mBio.01513-16
PMCID: PMC5050340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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