Article

Exploiting allele-specific transcriptional effects of subclonal copy number alterations for genotype-phenotype mapping in cancer cell populations

2023-01-10

Abstract excerpt

<h4>ABSTRACT</h4> Somatic copy number alterations drive aberrant gene expression in cancer cells. In tumors with high levels of chromosomal instability, subclonal copy number alterations (CNAs) are a prevalent feature which often result in heterogeneous cancer cell populations with distinct phenotypes 1 . However, the extent to which subclonal CNAs contribute to clone-specific phenotypes remains poorly understoo...

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Literature Corpus work: 57dd4015-bd3b-5469-87b7-10bbee12912d
DOI: 10.1101/2023.01.10.523464

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