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Inferring Phenotypes of Copy Number Clones in Cancer Populations Using TreeAlign.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2025

Shi Hongyu, Zatzman Matthew, Shah Sohrab, McPherson Andrew

Abstract excerpt

Somatic copy number changes modify gene expression and drive cancer development and progression. Single-cell techniques now allow for the profiling of both gene expression and copy number, opening the possibility of linking expression changes with copy number changes at a single-cell level. However, joint measurement of both expression and copy number from the same cell is not commonplace, and thus joint analysis...

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PMID: 40779108
DOI: 10.1007/978-1-0716-4566-6_7

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