Article

scAmp analyzes focal gene amplifications at single-cell resolution

2026-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Oncogene amplification on extrachromosomal DNA (ecDNA) is a common driver of tumor progression and is associated with acquired drug resistance and poor patient survival. While whole genome sequencing (WGS) studies have revealed the landscape of genes amplified on ecDNA in tumors, it remains challenging to study the subclonal heterogeneity and functional (e.g., transcriptomic) consequences of ecD...

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Literature Corpus work: 2c3b91e5-24aa-54a9-8eb9-d4967a787577
DOI: 10.64898/2026.02.14.705928

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