Article

Single-cell co-sequencing across human cancer reveals widespread clonal transience and rules of transcriptional response to gene dosage

2026-06-02

Abstract excerpt

<title>Abstract</title> <p>Intratumor heterogeneity drives disease progression, but even though subclonal copy number variation (CNV) is a major contributor to this heterogeneity1, its impact on cell phenotype is not fully understood. Here, by applying high-quality joint whole genome sequencing and mRNA profiling (co-sequencing) in single cells to patient samples across solid tumors and leukemias, we have analyze...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0bbdabba-682f-5b27-91e4-7cb48dbe1af3
DOI: 10.21203/rs.3.rs-9130645/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell co-sequencing across human cancer reveals widespread clonal transience and rules of transcriptional response to gene dosageDOI 10.21203/rs.3.rs-9130645/v1Read

Principles of subclonal gene dosage across human cancerSemantic proximity Read

Exploiting allele-specific transcriptional effects of subclonal copy number alterations for genotype-phenotype mapping in cancer cell populationsSemantic proximity Read

Integrated single-cell whole genome sequencing and spatial transcriptomics reveal latent intra-tumoral heterogeneity in ovarian cancerSemantic proximity Read

Single-cell genomic variation induced by mutational processes in cancer.Semantic proximity Read

Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancerSemantic proximity Read

Mapping single-cell transcriptomes to copy number evolutionary treesSemantic proximity Read

Allele-specific transcriptional effects of subclonal copy number alterations enable genotype-phenotype mapping in cancer cells.Semantic proximity Read

Coalescing single-cell genomes and transcriptomes to decode breast cancer progression.Semantic proximity Read

Characterizing the allele- and haplotype-specific copy number landscape of cancer genomes at single-cell resolution with CHISELSemantic proximity Read

Evolutionary tracking of cancer haplotypes at single-cell resolutionSemantic proximity Read

Evolution of oncogene amplification across 86,000 cancer cell genomesSemantic proximity Read

Dynamic optimization of extrachromosomal DNA copy number drives tumour evolutionSemantic proximity Read