Article
Single-cell genomic variation induced by mutational processes in cancer.
Nature - 1 Dec 2022
Funnell Tyler, O'Flanagan Ciara H, Williams Marc J, McPherson Andrew, McKinney Steven, Kabeer Farhia, Lee Hakwoo, Salehi Sohrab, Vázquez-García Ignacio, Shi Hongyu, Leventhal Emily, Masud Tehmina, Eirew Peter, Yap Damian, Zhang Allen W, Lim Jamie L P, Wang Beixi, Brimhall Jazmine, Biele Justina, Ting Jerome, Au Vinci, Van Vliet Michael, Liu Yi Fei, Beatty Sean, Lai Daniel, Pham Jenifer, Grewal Diljot, Abrams Douglas, Havasov Eliyahu, Leung Samantha, Bojilova Viktoria, Moore Richard A, Rusk Nicole, Uhlitz Florian, Ceglia Nicholas, Weiner Adam C, Zaikova Elena, Douglas J Maxwell, Zamarin Dmitriy, Weigelt Britta, Kim Sarah H, Da Cruz Paula Arnaud, Reis-Filho Jorge S, Martin Spencer D, Li Yangguang, Xu Hong, de Algara Teresa Ruiz, Lee So Ra, Llanos Viviana Cerda, Huntsman David G, McAlpine Jessica N, Shah Sohrab P, Aparicio Samuel
Abstract excerpt
How cell-to-cell copy number alterations that underpin genomic instability1 in human cancers drive genomic and phenotypic variation, and consequently the evolution of cancer2, remains understudied. Here, by applying scaled single-cell whole-genome sequencing3 to wild-type, TP53-deficient and TP53-deficient;BRCA1-deficient or TP53-deficient;BRCA2-deficient mammary epithelial cells (13,818 genomes), and to primary...
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