Article

Pro-autoimmune allele of tyrosine phosphatase, PTPN22, enhances tumor immunity

2021-03-18

Abstract excerpt

The 1858C>T allele of the tyrosine phosphatase PTPN22 ( causing amino acid substitution R620W in encoded protein Lyp) is present in 5-10% of the North American population and is strongly associated with numerous autoimmune diseases. Although much research has been done to define how this allele potentiates autoimmunity, the influence PTPN22 and its pro-autoimmune allele has in tumor immunity is poorly defined. T...

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Literature Corpus work: 577b9a9e-8f1d-5f09-a979-2e84220028c8
DOI: 10.1101/2021.03.17.435898

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