Article
An autoimmunity-associated allele of PTPN22 enhances innate antiviral immunity to protect against acute coronavirus infection.
Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2026
Bevis Alec M, Rosa Kathryn J L H, Schwarting Nancy, Cockerham Tammy R, Kerr Catherine M, More Sunil, Fehr Anthony R, Orozco Robin C
Abstract excerpt
Allelic variation can impact viral clearance and disease severity. Still, our understanding of the effect of the autoimmunity-associated allelic variant of Ptpn22 (PEP-R619W) on antiviral immunity remains incomplete, as previous reports have only focused on chronic lymphocytic choriomeningitis virus infection. This research defines how the loss of Ptpn22 (PEP-null) and PEP-R619W changes antiviral immunity during...
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