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Article

Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2021

Orozco Robin C, Marquardt Kristi, Mowen Kerri, Sherman Linda A

Abstract excerpt

The 1858C>T allele of the tyrosine phosphatase PTPN22 (causing amino acid substitution R620W in encoded protein lymphoid tyrosine phosphatase) is present in 5-10% of the North American population and is strongly associated with numerous autoimmune diseases. Although much research has been done to define how this allele potentiates autoimmunity, the influence PTPN22 and its proautoimmune allele have in tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34417261
DOI: 10.4049/jimmunol.2100304
PMCID: PMC8428750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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