Article
PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses.
eLife - 24 Mar 2023
Anderson Warren, Barahmand-Pour-Whitman Fariba, Linsley Peter S, Cerosaletti Karen, Buckner Jane H, Rawlings David J
Abstract excerpt
A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we utilize Crispr/Cas9 gene editing with donor DNA repair templates in human cord blood-derived, naive T cells to generate PTPN22 risk edited (620W), non-risk edited (620R), or knockout T cells from the same donor....
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