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Article

Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.

Immunology - 1 Jul 2018

Brownlie Rebecca J, Zamoyska Rose, Salmond Robert J

Abstract excerpt

A number of polymorphisms in immune-regulatory genes have been identified as risk factors for the development of autoimmune disease. PTPN22 (that encodes a tyrosine phosphatase) has been associated with the development of several autoimmune diseases, including type 1 diabetes, rheumatoid arthritis and systemic lupus erythematosus. PTPN22 regulates the activity and effector functions of multiple important immune...

Topics

Animals
Autoimmunity
Disease Models, Animal
Disease Susceptibility
Gene Expression Regulation
Humans
Immunomodulation
Lymphocyte Activation
Mice
Neoplasms
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatase, Non-Receptor Type 22

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 29512901
DOI: 10.1111/imm.12919
PMCID: PMC6002233

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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