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Article

Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.

Immunology - 1 Jul 2018

Brownlie Rebecca J, Zamoyska Rose, Salmond Robert J

Abstract excerpt

A number of polymorphisms in immune-regulatory genes have been identified as risk factors for the development of autoimmune disease. PTPN22 (that encodes a tyrosine phosphatase) has been associated with the development of several autoimmune diseases, including type 1 diabetes, rheumatoid arthritis and systemic lupus erythematosus. PTPN22 regulates the activity and effector functions of multiple important immune...

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Source

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Identifiers

PMID: 29512901
DOI: 10.1111/imm.12919
PMCID: PMC6002233

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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