Article
Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity.
PLoS pathogens - 1 Mar 2024
Orozco Robin C, Marquardt Kristi, Pratumchai Isaraphorn, Shaikh Anam Fatima, Mowen Kerri, Domissy Alain, Teijaro John R, Sherman Linda A
Abstract excerpt
The 1858C>T allele of the tyrosine phosphatase PTPN22 is present in 5-10% of the North American population and is strongly associated with numerous autoimmune diseases. Although research has been done to define how this allele potentiates autoimmunity, the influence PTPN22 and its pro-autoimmune allele has in anti-viral immunity remains poorly defined. Here, we use single cell RNA-sequencing and functional...
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