Article
The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.
Seminars in arthritis and rheumatism - 1 Jun 2021
Tizaoui Kalthoum, Terrazzino Salvatore, Cargnin Sarah, Lee Keum Hwa, Gauckler Philipp, Li Han, Shin Jae Il, Kronbichler Andreas
Abstract excerpt
The incidence of autoimmune diseases is increasing worldwide, thus stimulating studies on their etiopathogenesis, derived from a complex interaction between genetic and environmental factors. Genetic association studies have shown the PTPN22 gene as a shared genetic risk factor with implications in multiple autoimmune disorders. By encoding a protein tyrosine phosphatase expressed by the majority of cells...
Topics
- Animals
- Arthritis, Rheumatoid
- Autoimmune Diseases
- Autoimmunity
- B-Lymphocytes
- Genetic Predisposition to Disease
- Humans
- Lupus Erythematosus, Systemic
- Polymorphism, Single Nucleotide
- Protein Tyrosine Phosphatase, Non-Receptor Type 22