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Article

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.

Annual review of immunology - 1 Jan 2014

Bottini Nunzio, Peterson Erik J

Abstract excerpt

Inheritance of a coding variant of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is associated with increased susceptibility to autoimmunity and infection. Efforts to elucidate the mechanisms by which the PTPN22-C1858T variant modulates disease risk revealed that PTPN22 perfo...

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Source

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Identifiers

PMID: 24364806
DOI: 10.1146/annurev-immunol-032713-120249
PMCID: PMC6402334

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24364806-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

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