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An Autoimmunity-associated allele of <i>PTPN22</i> enhances innate antiviral immunity to protect against acute coronavirus infection

2025-07-18

Abstract excerpt

Allelic variation can impact viral clearance and disease severity. Still, our understanding of the effect of the autoimmunity-associated allelic variant of Ptpn22 (PEP-R619W) on antiviral immunity remains incomplete, as previous reports have only focused on chronic Lymphocytic Choriomeningitis virus (LCMV) infection. This research defines how the loss of Ptpn22 (PEP-null) and PEP-R619W changes antiviral immunity...

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Identifiers and source

Literature Corpus work
5aa6d747-d579-52bd-835b-a872985aa166
DOI
10.1101/2025.07.15.664967
Open publication

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An Autoimmunity-associated allele of <i>PTPN22</i> enhances innate antiviral immunity to protect against acute coronavirus infectionDOI 10.1101/2025.07.15.664967
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