Article
Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.
Frontiers in immunology - 1 Jan 2020
Purvis Harriet A, Clarke Fiona, Montgomery Anna B, Colas Chloe, Bibby Jack A, Cornish Georgina H, Dai Xuezhi, Dudziak Diana, Rawlings David J, Zamoyska Rose, Guermonprez Pierre, Cope Andrew P
Abstract excerpt
Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. Using Ptpn22-/- mice we...
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