Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

doi:10.1038/nature08869

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Article

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

Nature - 1 Apr 2010

Neumann Beate, Walter Thomas, Hériché Jean-Karim, Bulkescher Jutta, Erfle Holger, Conrad Christian, Rogers Phill, Poser Ina, Held Michael, Liebel Urban, Cetin Cihan, Sieckmann Frank, Pau Gregoire, Kabbe Rolf, Wünsche Annelie, Satagopam Venkata, Schmitz Michael H A, Chapuis Catherine, Gerlich Daniel W, Schneider Reinhard, Eils Roland, Huber Wolfgang, Peters Jan-Michael, Hyman Anthony A, Durbin Richard, Pepperkok Rainer, Ellenberg Jan

Abstract excerpt

Despite our rapidly growing knowledge about the human genome, we do not know all of the genes required for some of the most basic functions of life. To start to fill this gap we developed a high-throughput phenotypic screening platform combining potent gene silencing by RNA interference, time-lapse microscopy and computational image processing. We carried out a genome-wide phenotypic profiling of each of the...

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PMID: 20360735
DOI: 10.1038/nature08869
PMCID: PMC3108885

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