Article

Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma

2020-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Most B cell lymphomas originate from B cells that have germinal center (GC) experience and bear chromosome translocations and numerous point mutations. GCs B cells remodel their immunoglobulin (Ig) genes by somatic hypermutation (SHM) and class switch recombination (CSR) in their immunoglobulin (Ig) genes. Activation Induced Deaminase (AID) initiates CSR and SHM by generating U:G mismatches on I...

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Literature Corpus work: f4a90c78-4d27-5191-8502-6332ae0df411
DOI: 10.1101/2020.06.29.177303

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