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Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers

1 Jan 2012

Abstract excerpt

Activation-induced cytidine deaminase (AID) is an enzyme that is predominantly expressed in germinal center B cells and plays a pivotal role in immunoglobulin class switch recombination and somatic hypermutation for antibody (Ab) maturation. These two genetic processes endow Abs with protective functions against a multitude of antigens (pathogens) during humoral immune responses. In B cells, AID expression is...

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Identifiers

PMID: 23396757
DOI: 10.4110/in.2012.12.6.230

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