Article

Isolation of region-specific factors assembled on the Immunoglobulin heavy chain locus during antibody class switch recombination

2025-11-06

Abstract excerpt

Activation-Induced Cytidine Deaminase (AID) induces DNA double-strand breaks (DSBs) at the switch (S) regions of the Immunoglobulin heavy chain ( Igh ) locus, which are essential for Class Switch Recombination (CSR) and Somatic Hypermutation (SHM), key processes for effective antibody production. While AID activity is critical, its off-target effects, such as DSBs at the Myc locus, can cause chromosomal transloc...

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Literature Corpus work: 30023120-66be-5d8e-a3df-f801fa6bf98f
DOI: 10.1101/2025.11.04.677290

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