Balancing AID and DNA repair during somatic hypermutation.

doi:10.1016/j.it.2009.01.007

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Article

Balancing AID and DNA repair during somatic hypermutation.

Trends in immunology - 1 Apr 2009

Liu Man, Schatz David G

Abstract excerpt

Somatic hypermutation (SHM) of Ig genes in B cells is crucial for antibody affinity maturation. The reaction is initiated by cytosine deamination of Ig loci by activation induced deaminase (AID) and is completed by error-prone DNA repair enzyme processing of AID-generated uracils. The mechanisms that target SHM specifically to Ig loci are poorly understood. Recently, it has been demonstrated that although AID...

Topics

Animals
Antibody Affinity
Antibody Diversity
B-Lymphocytes
Cell Transformation, Neoplastic
Cytidine Deaminase
DNA
DNA Repair
Epigenesis, Genetic
Genes, Immunoglobulin
Humans
Mutation
Oncogenes
Somatic Hypermutation, Immunoglobulin
Substrate Specificity
AICDA (Activation-Induced Cytidine Deaminase)

Source

Open in PubMed

Identifiers

PMID: 19303358
DOI: 10.1016/j.it.2009.01.007

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