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Article

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.

Molecular cell - 22 Aug 2008

Conticello Silvestro G, Ganesh Karuna, Xue Kanmin, Lu Mason, Rada Cristina, Neuberger Michael S

Abstract excerpt

Activation-induced deaminase (AID) deaminates deoxycytidine residues in immunoglobulin genes, triggering antibody diversification. Here, by use of two-hybrid and coimmunoprecipitation assays, we identify CTNNBL1 (also known as NAP) as an AID-specific interactor. Mutants of AID that interfere with CTNNBL1 interaction yield severely diminished hypermutation and class switching. Targeted inactivation of CTNNBL1 in...

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Source

Identifiers

PMID: 18722174
DOI: 10.1016/j.molcel.2008.07.009

Genes

CTNNBL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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