A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.

doi:10.1016/j.immuni.2020.10.003

Article

A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.

Immunity - 17 Nov 2020

Yewdell William T, Kim Youngjun, Chowdhury Priyanka, Lau Colleen M, Smolkin Ryan M, Belcheva Kalina T, Fernandez Keith C, Cols Montserrat, Yen Wei-Feng, Vaidyanathan Bharat, Angeletti Davide, McDermott Adrian B, Yewdell Jonathan W, Sun Joseph C, Chaudhuri Jayanta

Abstract excerpt

Precise targeting of activation-induced cytidine deaminase (AID) to immunoglobulin (Ig) loci promotes antibody class switch recombination (CSR) and somatic hypermutation (SHM), whereas AID targeting of non-Ig loci can generate oncogenic DNA lesions. Here, we examined the contribution of G-quadruplex (G4) nucleic acid structures to AID targeting in vivo. Mice bearing a mutation in Aicda (AIDG133V) that disrupts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.

Abstract excerpt

Topics

Related research