Article

T cell-derived IFNγ instructs ECM crosslinking by cardiac fibroblasts through LOXL3 in experimental cardiometabolic HFpEF

2026-03-18

Abstract excerpt

<h4>Background</h4> Heart failure with preserved ejection fraction (HFpEF) is a major clinical challenge characterized by diastolic dysfunction. Left ventricular stiffening and inflammation are hallmarks of HFpEF, yet the contribution of extracellular matrix (ECM) stiffness and the immune–stromal mechanisms driving ECM stiffening in cardiometabolic HFpEF remain poorly understood. <h4>Methods</h4> We used the mur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 554538e5-3544-5023-a61a-4a71a5b02ded
DOI: 10.64898/2026.03.16.712110

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

T cell-derived IFNγ instructs ECM crosslinking by cardiac fibroblasts through LOXL3 in experimental cardiometabolic HFpEFDOI 10.64898/2026.03.16.712110Read

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in murine heart failure with preserved ejection fractionSemantic proximity Read

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac FibrosisSemantic proximity Read

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart FailureSemantic proximity Read

Myeloid Cell Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection FractionSemantic proximity Read

Identification of CD4 <sup>+</sup> Sub-population of Resident Cardiac Fibroblasts Linked to Myocardial FibrosisSemantic proximity Read

Systems-Level Transcriptomics Maps Multilevel Remodeling and Pathway-Selective Translational Alignment Across Murine Models of Cardiometabolic HFpEFSemantic proximity Read

Cross-Species Multi-Omics Profiling Identifies Conserved Activated Valvular Interstitial Cell Population Driving Myxomatous Mitral Valve DegenerationSemantic proximity Read

Cardiac fibroblast sub-types in vitro reflect pathological cardiac remodeling in vivoSemantic proximity Read

Linking LOXL2 to Cardiac Interstitial FibrosisSemantic proximity Read

Hypertension-mediated cardiac fibrosis is a mechanical process initiated by smooth muscle cellsSemantic proximity Read

IFIT3 Knockdown Attenuates Pressure-Overload-Induced Cardiac Inflammation and Remodeling Through a JNK/H3K9 Lactylation-Associated MechanismSemantic proximity Read

Macrophage Histone Lactylation Drives Inflammatory Activation in Heart Failure via the IFIT3/JNK Signaling AxisSemantic proximity Read