Article

Macrophage Histone Lactylation Drives Inflammatory Activation in Heart Failure via the IFIT3/JNK Signaling Axis

2026-02-19

Abstract excerpt

<title>Abstract</title> <p> Aims: Heart failure (HF) is characterized by persistent inflammation, although its underlying immunometabolic regulatory mechanisms remain unclear. We investigated whether the interferon-induced protein <italic>IFIT3</italic> drives inflammatory activation in cardiac macrophages and defined its downstream signaling and epigenetic regulatory mechanisms. <h4>Methods:</h4> We performe...

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Literature Corpus work: 66dc538d-b9da-5060-b599-ca165e21c15d
DOI: 10.21203/rs.3.rs-8830080/v1

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