Article

Systems-Level Transcriptomics Maps Multilevel Remodeling and Pathway-Selective Translational Alignment Across Murine Models of Cardiometabolic HFpEF

2026-05-04

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous cardiometabolic syndrome in which the molecular programs linking metabolic stress to myocardial remodeling and diastolic dysfunction remain incompletely defined. We integrated ventricular RNA sequencing with pathway activity profiling, transcription factor inference, cell-type enrichment, phenotype association, elastic-net severity modeling,...

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Literature Corpus work: 94949589-b776-5aaa-934f-4a4cdcd55b41
DOI: 10.64898/2026.04.30.721824

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