Article

Cross-Species Multi-Omics Profiling Identifies Conserved Activated Valvular Interstitial Cell Population Driving Myxomatous Mitral Valve Degeneration

2026-03-25

Abstract excerpt

<h4>Background</h4> Primary mitral regurgitation resulting from mitral valve prolapse can lead to life-threatening complications, including arrhythmias, heart failure, and sudden cardiac death. Mitral valve prolapse is classically associated with myxomatous mitral valve degeneration, characterized by leaflet thickening, extracellular matrix disorganization, and progressive structural remodeling. Valvular intersti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f9c776c-2e17-5d68-83d7-a8859ede9cb1
DOI: 10.64898/2026.03.23.713796

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross-Species Multi-Omics Profiling Identifies Conserved Activated Valvular Interstitial Cell Population Driving Myxomatous Mitral Valve DegenerationDOI 10.64898/2026.03.23.713796Read

Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologiesSemantic proximity Read

Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve DiseaseSemantic proximity Read

Spatial transcriptomics reveals layered immune-metabolic architecture of giant cell myocarditisSemantic proximity Read

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model.Semantic proximity Read

Identifying Key Cells for Fibrosis by Systematically Calling Cell Type–Phenotype Associations across Massive Heterogenous DatasetsSemantic proximity Read

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in murine heart failure with preserved ejection fractionSemantic proximity Read

Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving DiseaseSemantic proximity Read

Macrophage recruitment is a hallmark of non-syndromic myxomatous mitral valve disease.Semantic proximity Read

Dynamic Heterogeneity of the Heart Valve Interstitial Cell Population in Mitral Valve Health and DiseaseSemantic proximity Read

Genetic Architecture and Myocardial Fibrotic Remodeling in Mitral Valve ProlapseSemantic proximity Read

Decoding and Targeting Coordinated CDKN1A and CDKN2A Senescence Programs in ECM-Dominant Cardiovascular PathologiesSemantic proximity Read

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read