Article

<i>De novo</i> assembly, delivery and expression of a 101 kb human gene in mouse cells

2018-09-20

Abstract excerpt

Design and large-scale synthesis of DNA has been applied to the functional study of viral and microbial genomes. New and expanded technology development is required to unlock the transformative potential of such bottom-up approaches to the study of larger mammalian genomes. Two major challenges include assembling and delivering long DNA sequences. Here we describe a pipeline for de novo DNA assembly and delivery...

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Literature Corpus work: 9edc7adf-4c9d-52cd-95de-9ca8b5e8dc38
DOI: 10.1101/423426

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