Article

Linear Assembly of a Human Y Centromere

2017-07-31

Abstract excerpt

The human genome reference sequence remains incomplete due to the challenge of assembling long tracts of near-identical tandem repeats-in centromeric regions. To address this, we have implemented a nanopore sequencing strategy to generate high quality reads that span hundreds of kilobases of highly repetitive DNAs. Here, we use this advance to produce a sequence assembly and characterization of the centromeric reg...

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Literature Corpus work: ae6b9904-a11d-5794-99aa-0272ff165883
DOI: 10.1101/170373

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