Article

Molecular Basis for state-dependent drug block of Kv11.1 (HERG) potassium channels

2024-07-16

Abstract excerpt

<h4>Background: </h4> and Purpose: Many structurally and therapeutically diverse drugs block the human ether-à-go-go related gene (HERG) potassium channel, predisposing patients to an increased risk of arrythmias and sudden cardiac death. Many drugs show state-dependence of block, exhibiting a greater preference for block of the inactivated state. Five key residues within the central pore cavity of HERG have been...

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Literature Corpus work: ecf40d91-8c2e-5ecd-a647-b8478639a3d8
DOI: 10.22541/au.172115262.22360182/v1

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