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Article

Voltage sensor movement in the hERG K+ channel.

Novartis Foundation symposium - 1 Jan 2005

Piper David R, Sanguinetti Michael C, Tristani-Firouzi Martin

Abstract excerpt

The critical role of hERG in the maintenance of normal cardiac electrical activity derives from its unusual gating properties: slow channel activation and fast inactivation. To characterize voltage sensor movement associated with slow activation and fast inactivation, we measured gating currents from wild-type and mutant hERG channels. Fast and slow gating components were observed that differed 100-fold in their...

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Identifiers

PMID: 16050261
DOI: 10.1002/047002142x.ch5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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