Article
Fast and slow voltage sensor movements in HERG potassium channels.
The Journal of general physiology - 1 Mar 2002
Smith Paula L, Yellen Gary
Abstract excerpt
HERG encodes an inwardly-rectifying potassium channel that plays an important role in repolarization of the cardiac action potential. Inward rectification of HERG channels results from rapid and voltage-dependent inactivation gating, combined with very slow activation gating. We asked whether the voltage sensor is implicated in the unusual properties of HERG gating: does the voltage sensor move slowly to account...
Topics
- Amino Acid Sequence
- Animals
- Cation Transport Proteins
- Ether-A-Go-Go Potassium Channels
- Ion Channel Gating
- Molecular Sequence Data
- Mutation
- Potassium Channels
- Potassium Channels, Voltage-Gated
- Xenopus