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Article

Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel.

Communications biology - 24 Feb 2022

Costa Flavio, Guardiani Carlo, Giacomello Alberto

Abstract excerpt

The elusive activation/deactivation mechanism of hERG is investigated, a voltage-gated potassium channel involved in severe inherited and drug-induced cardiac channelopathies, including the Long QT Syndrome. Firstly, the available structural data are integrated by providing a homology model for the closed state of the channel. Secondly, molecular dynamics combined with a network analysis revealed two distinct...

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Identifiers

PMID: 35210539
DOI: 10.1038/s42003-022-03074-9
PMCID: PMC8873449

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