Article

Structural modeling of the hERG potassium channel and associated drug interactions

2021-07-09

Abstract excerpt

The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go - Related Gene (hERG) is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential. Gating of hERG channel is characterized by rapid, voltage-dependent, C-type inactivation, which blocks ion conduction and is suggested to involve constriction of the selectivity filter. Mutations S620T a...

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Literature Corpus work: f780bd72-7b5b-5039-a007-e14e0efcd58a
DOI: 10.1101/2021.07.08.451699

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