Article

An intracellular hydrophobic nexus is critical for slow deactivation in hERG channels

2023-03-05

Abstract excerpt

Slow deactivation is a critical biophysical and physiological property of voltage-gated K + channels encoded by the human Ether-à-go-go-Related Gene ( hERG ). hERG channel deactivation is modulated by interactions between intracellular N-terminal Per-Arnt-Sim (PAS) and C-terminal cyclic nucleotide-binding homology (CNBh) domains. The PAS domain is multipartite, comprising a globular domain (residues 26-136) and...

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Identifiers and source

Literature Corpus work: 8d837a11-3699-548f-85e7-23cf8d669e57
DOI: 10.1101/2023.03.04.531007

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