Article

AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes

2024-06-20

Abstract excerpt

Oxidative protein folding in the endoplasmic reticulum (ER) is essential for all eukaryotic cells yet generates hydrogen peroxide (H 2 O 2 ), a reactive oxygen species (ROS). The ER-transmembrane protein that provides reducing equivalents to ER and guards the cytosol for antioxidant defense remains unidentified. Here we combine AlphaFold2-based and functional reporter screens in C. elegans to discover a previou...

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Literature Corpus work: 5442daab-cf23-5b8f-b41e-125b865441b0
DOI: 10.1101/2024.06.19.599784

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