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Article

Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.

Science (New York, N.Y.) - 27 Mar 2009

Jonikas Martin C, Collins Sean R, Denic Vladimir, Oh Eugene, Quan Erin M, Schmid Volker, Weibezahn Jimena, Schwappach Blanche, Walter Peter, Weissman Jonathan S, Schuldiner Maya

Abstract excerpt

Protein folding in the endoplasmic reticulum is a complex process whose malfunction is implicated in disease and aging. By using the cell's endogenous sensor (the unfolded protein response), we identified several hundred yeast genes with roles in endoplasmic reticulum folding and systematically characterized their functional interdependencies by measuring unfolded protein response levels in double mutants. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19325107
DOI: 10.1126/science.1167983
PMCID: PMC2877488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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