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Article

ERO1A inhibition mitigates neuronal ER stress and ameliorates UBQLN2ALS phenotypes in Drosophila melanogaster.

Progress in neurobiology - 1 Nov 2024

Yeewa Ranchana, Sangphukieo Apiwat, Jantaree Phatcharida, Wongkummool Wasinee, Yamsri Titaree, Poompouang Siwat, Chaiyawat Parunya, Lo Piccolo Luca, Jantrapirom Salinee

Abstract excerpt

Modulating the ER stress pathway holds therapeutic promise for neurodegenerative diseases; however, identifying optimal targets remains challenging. In this study, we conducted an unbiased screening to systematically search for commonly up-regulated proteins in ER stress-related neurodegenerative conditions, with endoplasmic reticulum oxidoreductase 1 alpha (ERO1A) emerging as a significant hit. Further...

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Identifiers

PMID: 39395630
DOI: 10.1016/j.pneurobio.2024.102674

Genes

ERO1A

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