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Article

A conserved cysteine-based redox mechanism sustains TFEB/HLH-30 activity under persistent stress.

The EMBO journal - 1 Feb 2021

Martina José A, Guerrero-Gómez David, Gómez-Orte Eva, Antonio Bárcena José, Cabello Juan, Miranda-Vizuete Antonio, Puertollano Rosa

Abstract excerpt

Mammalian TFEB and TFE3, as well as their ortholog in Caenorhabditis elegans HLH-30, play an important role in mediating cellular response to a variety of stress conditions, including nutrient deprivation, oxidative stress, and pathogen infection. In this study, we identify a novel mechanism of TFEB/HLH-30 regulation through a cysteine-mediated redox switch. Under stress conditions, TFEB-C212 undergoes oxidation,...

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Identifiers

PMID: 33314217
DOI: 10.15252/embj.2020105793
PMCID: PMC7849306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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