Article
The FOXO transcription factor DAF-16 bypasses ire-1 requirement to promote endoplasmic reticulum homeostasis.
Cell metabolism - 4 Nov 2014
Safra Modi, Fickentscher Rolf, Levi-Ferber Mor, Danino Yehuda M, Haviv-Chesner Anat, Hansen Malene, Juven-Gershon Tamar, Weiss Matthias, Henis-Korenblit Sivan
Abstract excerpt
The unfolded protein response (UPR) allows cells to adjust the capacity of the endoplasmic reticulum (ER) to the load of ER-associated tasks. We show that activation of the Caenorhabditis elegans transcription factor DAF-16 and its human homolog FOXO3 restore secretory protein metabolism when the UPR is dysfunctional.We show that DAF-16 establishes alternative ER-associated degradation systems that degrade...
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