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Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in <i>Caenorhabditis elegans</i>

2025-12-05

Abstract excerpt

Mitochondrial redox homeostasis is essential for cellular metabolism and organismal development. To investigate the consequences of disrupting redox homeostasis in this organelle in a metazoan organism, we generated a double mutant lacking mitochondrial glutathione reductase ( gsr-1a ) and thioredoxin reductase ( trxr-2 ) genes in Caenorhabditis elegans . While gsr-1a or trxr-2 single mutants are phenotypical...

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Literature Corpus work
3f786162-14fa-5849-b1a8-9bf15f794256
DOI
10.64898/2025.12.03.691999
Open publication

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Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in <i>Caenorhabditis elegans</i>DOI 10.64898/2025.12.03.691999
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