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Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

9 Mar 2010

Abstract excerpt

Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the Caenorhabditis elegans SKN-1; and the Drosophila CncC comprise a subgroup of Cnc factors that mediate adaptive responses to cellular stress. The most studied stress-activated Cnc factor is Nrf2, which orchestrates the transcriptional response of...

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PMID: 20215646
DOI: 10.1126/scisignal.3112re3

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