Article
Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans.
Redox biology - 1 Jun 2026
Valenzuela-Villatoro Marina, de la Cruz-Ruiz Patricia, Guerrero-Gómez David, Gómez-Orte Eva, Schiavi Alfonso, Maglioni Silvia, Montero Mayte, Fonteriz Rosalba I, Casas-Martínez José Carlos, Briand Nicole E, Xu Jingxiu, Rodriguez-Palero María Jesús, Artal-Sanz Marta, Olek Katarzyna, Polaczyk Justyna, Turek Michal, Pokrzywa Wojciech, Xu Suhong, Irazoqui Javier E, McDonagh Brian, Álvarez Javier, Olmedo María, Ventura Natascia, Cabello Juan, Miranda-Vizuete Antonio
Abstract excerpt
Mitochondrial redox homeostasis is essential for cellular metabolism and organismal development. To investigate the consequences of disrupting redox homeostasis in this organelle in a metazoan organism, we generated a double mutant lacking mitochondrial glutathione reductase (gsr-1a) and thioredoxin reductase (trxr-2) genes in Caenorhabditis elegans. While gsr-1a or trxr-2 single mutants are phenotypically...
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