Article

ER stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

2019-09-18

Abstract excerpt

<h4>SUMMARY</h4> Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated and is implicated in metabolic diseases when compromised. Using an engineered sensor that exclusively activates the unfolded protein response (UPR) during aberrant ER membrane lipid composition, we identified pathways beyond lipid metabolism that are necessary to maintain ER integrity in yeast and are conserved in C. elega...

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Literature Corpus work: ca4d4730-9741-584a-84b5-88312d96d862
DOI: 10.1101/774133

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